Established in 2017, the Airport Health Organisation (APHO), Calicut serves as the designated public health authority at Calicut International Airport, overseeing the implementation of public health measures for international travellers in accordance with national and international health regulations.

Till March 2022, APHO Calicut operated under the administrative oversight of the Senior Regional Director, Regional Office of Health and Family Welfare Trivandrum. Subsequently it was designated as a separate administrative office.