Established in 2011, the Airport Health Organisation (APHO), Trivandrum serves as the designated public health authority at Thiruvananthapuram International Airport, overseeing the implementation of public health measures for international travellers in accordance with national and international health regulations.

Till March 2022, APHO Trivandrum operated under the administrative oversight of the Senior Regional Director, Regional Office of Health and Family Welfare Trivandrum. Subsequently it was designated as a separate administrative office.