Established in 1963, the Port Health Organisation (PHO), Tuticorin serves as the designated public health authority at V. O. Chidambaranar Port overseeing the implementation of public health measures for international travellers in accordance with national and international health regulations.

The organisation was initially established at Mandapam Camp in 1963, and was shifted to Tuticorin following the suspension of international shipping activities at Mandapam, and commenced full-fledged operations at Tuticorin on 2007.

To strengthen preparedness for public health surveillance, PHO Tuticorin is equipped with a dedicated vector surveillance laboratory and facilities for training, conferences, and capacity-building activities

PHO Tuticorin is also an authorized Yellow Fever Vaccination Centre.